New article published: Leleu et al, 2024

Congratulations to Dr. Leleu and colleagues on the publication of their article presenting the final results of the DEP KP80 study of lung cancer screening in France in the journal EBioMedicine. We are delighted to have contributed to the success of this article!

Lung cancer is responsible for 𝟐 𝐦𝐢𝐥𝐥𝐢𝐨𝐧 𝐝𝐞𝐚𝐭𝐡𝐬 𝐩𝐞𝐫 𝐲𝐞𝐚𝐫 and is the leading cause of cancer-related death. Despite active research to 𝐛𝐞𝐭𝐭𝐞𝐫 𝐝𝐢𝐚𝐠𝐧𝐨𝐬𝐞 these cancers, they are often detected 𝐚𝐭 𝐚𝐧 𝐚𝐝𝐯𝐚𝐧𝐜𝐞𝐝 𝐬𝐭𝐚𝐠𝐞. The 𝐃𝐄𝐏 𝐊𝐏𝟖𝟎 study aimed at investigating the 𝐟𝐞𝐚𝐬𝐢𝐛𝐢𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐞𝐟𝐟𝐞𝐜𝐭𝐢𝐯𝐞𝐧𝐞𝐬𝐬 in real-life conditions of lung cancer screening by low-dose CT in the French department of Somme in high-risk patients.

Patients underwent three 𝐥𝐨𝐰-𝐝𝐨𝐬𝐞 𝐂𝐓 screening examinations. Between 2016 and 2020, 1,254 patients were included in the study. The screening detected 𝟒𝟐 𝐥𝐮𝐧𝐠 𝐜𝐚𝐧𝐜𝐞𝐫𝐬. Of these, 30 were stage I or II, and 34 could be operated on. Final analysis of the three screening series showed an overall 𝐩𝐨𝐬𝐢𝐭𝐢𝐯𝐞 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐢𝐯𝐞 𝐯𝐚𝐥𝐮𝐞 𝐨𝐟 𝟒𝟖%, and a 𝐧𝐞𝐠𝐚𝐭𝐢𝐯𝐞 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐢𝐯𝐞 𝐯𝐚𝐥𝐮𝐞 𝐨𝐟 𝟏𝟎𝟎%. This real-life study therefore 𝐜𝐨𝐧𝐟𝐢𝐫𝐦𝐞𝐝 𝐭𝐡𝐞 𝐟𝐞𝐚𝐬𝐢𝐛𝐢𝐥𝐢𝐭𝐲 𝐚𝐧𝐝 𝐞𝐟𝐟𝐞𝐜𝐭𝐢𝐯𝐞𝐧𝐞𝐬𝐬 of lung cancer screening.

However, the fact that the number of participants gradually decreased with each series of examinations underlines the 𝐢𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐜𝐞 𝐨𝐟 𝐨𝐩𝐭𝐢𝐦𝐢𝐳𝐢𝐧𝐠 𝐭𝐡𝐞 𝐨𝐫𝐠𝐚𝐧𝐢𝐳𝐚𝐭𝐢𝐨𝐧 of medical institutions, and the need to use multidisciplinary structures to maximize patient participation. The article is already available on the journal's website! 𝐃𝐎𝐈: 𝟏𝟎.𝟏𝟎𝟏𝟔/𝐣.𝐞𝐛𝐢𝐨𝐦.𝟐𝟎𝟐𝟒.𝟏𝟎𝟓𝟑𝟗𝟔