New published article: Jadot et al. 2024

Congratulations to Dr. Jadot and colleagues on the publication of their case report of a patient with adenovirus-associated acute interstitial nephritis in the journal Clinical Case Reports. We are delighted to have contributed to the success of this article!

𝐀𝐜𝐮𝐭𝐞 𝐢𝐧𝐭𝐞𝐫𝐬𝐭𝐢𝐭𝐢𝐚𝐥 𝐧𝐞𝐩𝐡𝐫𝐢𝐭𝐢𝐬 (AIN) accounts for almost 10% of cases of acute renal failure, and may be 𝐝𝐫𝐮𝐠-𝐢𝐧𝐝𝐮𝐜𝐞𝐝 𝐨𝐫 𝐯𝐢𝐫𝐚𝐥 𝐢𝐧 𝐨𝐫𝐢𝐠𝐢𝐧. This article reports the 𝐜𝐚𝐬𝐞 𝐨𝐟 𝐚 𝟒𝟗-𝐲𝐞𝐚𝐫-𝐨𝐥𝐝 𝐰𝐨𝐦𝐚𝐧 in remission from acute myeloid leukaemia who presented with hematuria, pain, fever, rash, and painful lumbar percussion 3 months after allogeneic hematopoietic stem cell transplantation.

Results of abdominal CT and urinary tract ultrasound 𝐰𝐞𝐫𝐞 𝐧𝐨𝐫𝐦𝐚𝐥 and tests for viral infection 𝐰𝐞𝐫𝐞 𝐧𝐞𝐠𝐚𝐭𝐢𝐯𝐞. With fever persisting and qPCR results pending, the patient underwent 𝐟𝐥𝐮𝐨𝐫𝐨𝐝𝐞𝐨𝐱𝐲𝐠𝐥𝐮𝐜𝐨𝐬𝐞 (𝟏𝟖𝐅𝐃𝐆) 𝐩𝐨𝐬𝐢𝐭𝐫𝐨𝐧 𝐞𝐦𝐢𝐬𝐬𝐢𝐨𝐧 𝐭𝐨𝐦𝐨𝐠𝐫𝐚𝐩𝐡𝐲, which identified corticomedullary thickening associated with 18FDG uptake in the renal parenchyma. qPCR then identified the 𝐩𝐫𝐞𝐬𝐞𝐧𝐜𝐞 𝐨𝐟 𝐚𝐧 𝐚𝐝𝐞𝐧𝐨𝐯𝐢𝐫𝐮𝐬. After treatment, the symptoms disappeared and renal function returned to normal.

With this case report, the authors concluded that adenovirus-associated AIN should 𝐚𝐥𝐰𝐚𝐲𝐬 𝐛𝐞 𝐜𝐨𝐧𝐬𝐢𝐝𝐞𝐫𝐞𝐝 𝐢𝐧 𝐭𝐡𝐞 𝐝𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐭𝐢𝐚𝐥 𝐝𝐢𝐚𝐠𝐧𝐨𝐬𝐢𝐬 of acute renal failure after allogeneic bone marrow transplantation. In addition, although this test does not provide a definitive diagnosis of adenovirus-associated AIN, 𝟏𝟖𝐅𝐃𝐆 𝐏𝐄𝐓 𝐬𝐜𝐚𝐧𝐬 𝐦𝐚𝐲 𝐛𝐞 𝐮𝐬𝐞𝐟𝐮𝐥, particularly when a biopsy is not possible.