Teeth regrowth: soon possible?

Tooth loss, whether due to congenital or acquired disease, or accident, is very common. Is tooth regeneration a possible solution?

In adults, the congenital absence of one or more teeth is called 𝐝𝐞𝐧𝐭𝐚𝐥 𝐚𝐠𝐞𝐧𝐞𝐬𝐢𝐬. There are also various acquired causes of permanent tooth loss, such as 𝐚𝐜𝐜𝐢𝐝𝐞𝐧𝐭𝐬, 𝐭𝐨𝐨𝐭𝐡 𝐝𝐞𝐜𝐚𝐲, 𝐨𝐫 𝐩𝐞𝐫𝐢𝐨𝐝𝐨𝐧𝐭𝐢𝐭𝐢𝐬. Tooth loss then occurs naturally with old age. Poor oral hygiene and unhealthy eating habits undoubtedly contribute to tooth loss. For over 20 years, research has been testing treatment solutions 𝐨𝐭𝐡𝐞𝐫 𝐭𝐡𝐚𝐧 𝐢𝐦𝐩𝐥𝐚𝐧𝐭𝐬 𝐚𝐧𝐝 𝐩𝐫𝐨𝐬𝐭𝐡𝐞𝐬𝐞𝐬.

Among the solutions proposed, 𝐢𝐧𝐚𝐜𝐭𝐢𝐯𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐭𝐡𝐞 𝐔𝐒𝐀𝐆-𝟏 𝐠𝐞𝐧𝐞 can improve dental agenesis and subsequently promote tooth morphogenesis in 𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐚𝐥𝐥𝐲 𝐦𝐨𝐝𝐢𝐟𝐢𝐞𝐝 𝐦𝐢𝐜𝐞. In addition, treatment with 𝐚𝐧𝐭𝐢-𝐔𝐒𝐀𝐆-𝟏 𝐚𝐧𝐭𝐢𝐛𝐨𝐝𝐢𝐞𝐬 has been shown to 𝐩𝐫𝐨𝐦𝐨𝐭𝐞 𝐭𝐨𝐨𝐭𝐡 𝐫𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐨𝐧 in mice. This type of therapeutic solution would be 𝐦𝐨𝐫𝐞 𝐞𝐜𝐨𝐧𝐨𝐦𝐢𝐜𝐚𝐥 and use natural dentition, compared with dental implants and prostheses.

A clinical trial is due to be launched at Kitano Hospital in Osaka, to 𝐭𝐞𝐬𝐭 𝐭𝐡𝐞 𝐬𝐚𝐟𝐞𝐭𝐲 𝐨𝐟 𝐚 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐝𝐞𝐚𝐜𝐭𝐢𝐯𝐚𝐭𝐢𝐧𝐠 𝐭𝐡𝐞 𝐔𝐒𝐀𝐆-𝟏 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 in patients with congenital tooth loss, aged between 2 and 7, and with at least four teeth missing from birth. If the treatment is effective and safe, it will then be tested in patients with total absence of teeth (oligodontia).